I am thinking of running this campaign in three parts: Bloodlines, Currents, and Convergence. The first will focus on the families that have run throughout Shem's history, the second will be about the forces that have driven the game to where it is, and the third will bring everything together. Each part would feature a different set of PCs, and the final session(s) would be some sort of true convergence. The third arc might even switch between parties and viewpoints. I will mark where I suggest various PCs might best be featured.

No suggestion is set in stone.

So far, playable:

Kaylie:
Balkis Windsong (Currents), the Queen of Cats
Kateri Riverwalker (Currents), the Archer
Rosiel Rhea (unknown), the Cursed Angel
Matrim Alistair Argent (Bloodlines), the Chosen of Alabaster, the Argent Bard
Alice Higgins (Bloodlines), the Warden of the Camera
Skia (Currents), the Shadowcat
Davan Asher (Bloodlines), the Dedicate of Azure-Amethyst
Leia Sevensdaughter, Face of Fortune, Eternal Child
Azuros, Blue Falcon Manifest
Feliciir, Face of Fortune, Amethyst Dragon Reever
Sol Felicitus, Amethyst Corona
Soma, (Currents) Valkyrie Priestess
Inteus, (Currents) Servant of the Huntress

Benjesus:
Lucas Tove (Bloodlines), the Curseweaver
Aldo Murgen (Currents), the Silver Walker
Nik'laas Myrmex (Currents), the Nexus of the Thrax
Subiquim Ixioj (any), the Voice of the Void
Zada Soshi (Currents), the Angel of Knowledge
Mikhail Mao (Currents), the Apotheosis Consultant
Lyra Franco (Currents), the Altered Voice

JT:
Katya Nikolaev (Bloodlines), the Keeper of Mana
Arlie Battisto (Bloodlines), the Servant of Interesting Life
Mother Viollca Lovell Driver (Bloodlines), the Shade Speaker
Curl, the High Servitor of Water (Currents)
Maurin (Currents), the Prophet of Force, the Drifter
Quacklin Grippytop (Bloodlines), Avatar of Belle Point
Jatasura Kauravas (any) , Rakshasa Debt Collector
Ivan Khitrovo (Currents), Irritokineticist Knight of the Black Velvet
Drifa, (Currents) Valkyrie Shieldmaiden

Dani:
Albert Renkarr (Bloodlines), the Speaker of the People
Arsul Toutant (Bloodlines), the Prophet Toutant
Argana, (Currents) the Queen of Metal
Tilluel (Currents), the Rains
Isidore Firfov, (Currents) the Re Woven
Hanisim, (Currents) Servant of Skill
Valtid, (Currents) Valkyrie Krewe Leader

Nathan:
St Theresa (Currents), the Listener
Paul Driver (Bloodlines), the Keeper of Justice
Deienira, (Currents) the Handmaiden of Strength
Angela Murray, (Bloodlines), High Servitor of the WAR GOD
Gerrick MacBoon (Bloodlines), the Warden of Inverray
Marcus Johansen, (Currents) Servant of Wisdom
Ilse , (Currents) Valkyrie Weapon-Maker

Ian:
Llunethan (Currents), the Prophet of Contradiction
Ramiro Azul (Currents), Cursed Lord of the Void

Beccah:
Deyn Amaethon (Currents), the Sword of Stones
Naitaka Citlali (Currents), the Vulpine Scout
Avery Colzayre (Bloodlines?), Nimbleford, the Servitor of the Unicorn
Gabriel Corbannon (Bloodlines), Luck Savant
Royce Cormagen (Currents), the Master of the Albatross
Chiyo Date, (Bloodlines) Servant of the Matriarch
Jana, (Currents) Valkyrie Scout

Melissa:
Hichew Loufburrow (Bloodlines), the Grand Pooka
Kez (Currents), the Servant of Order

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NPCs:
Fitz Romaine, the High Servitor of Balance
Marilyna Isral, the Night Watch
Marilyna Firesong, the Servant of the People
Robin Goodfellow, the Trickster
Edela, the Seneschal of the Court
Rumbleford, the Servitor of the Unicorn
Jack the Diamond, the Prince of Wealth
The Balladeer, the Balladeer
Emily Brand Argent, the Keeper of Kindness
Mercy Driver, the Archmage of Mercy
Cary Driver, the Corruptor
Elena Driver, the Roma Mother
Pavel Driver, the Silver Sword
Daisy, the Griffin Keeper
Annavera Firewalker, the Firewalker
Caspian Starheart, the Planar Linguist
Dritta Lovell, the Metaphysical Philosopher
Dukat Toutant, the Honorable General
JD Battisto, the Summer Sailor
Rellie Battisto, the Spring Sorceress
Barry Battisto, the High Citizen
Fane Crow, the Weaver of Crows
Belizo Avam, the Fool of Chaos
Angela Rue, Red-Handed Inhuman
Hossafahr ibn Tara'hin, Servitor of Magic, Archalchemist & Prudence, his teddy bear
Oliver Manvi, Hand of Vision
Saladin Steelhorse, Angela's Steed
Hielan Durrow, Shepherd of Kindness
Wistlyn, Tree Sage
Ateg Drazik, Shaman of Cobalt Flames
Cuniaim, Vahana of Thorns
Vallane, Swan Crone, Marred by the Webweaver
Eviane, Sapphire Sword
Tecumseh, Warden of Skybreak
Calypso, Satherian Leader
Tao Seung, Poet and Merchant
Lyravenne Brynella, Moonwife
Erennane, Thief of the Moons
Kentosane, Archmage of Koolihama
Almaran, Arch Geomagus
Allasa Crowweaver, Crowe Consequent
Nourik Gitak, Custodian of Hours
Cleyuk, High Priest of Contradiction
Ikara, Risher of the Brotherhood
Noqus, Watcher of the Albatross
Artemis Crow, Demonologist
Gasthis Zensora, Senescahl of the Rat-God
Khalif Benin, Prophet Avett
Thurdha, Nexus of Elementals
The Veil, Spymaster of the Sathers
Craalath, Son of the Bheriya
The Bheriya, Burning Wolf of Vimala
Sol Invictus, Invincible Sun
Margaret MacBoon, Swan Sister
Ansley Fraser, Lady of Inverray
Cuthbert, Haugrad, and Malcolm the Younger, Wolves of Inverray
Yombe Okagua, Un-Stuck in Time
Waylan Rhames, Obiefune's Apprentice